diff --git a/meta-python/recipes-devtools/python/python3-smbus/0001-Use-setuptools-as-distutils-is-deprecated.patch b/meta-python/recipes-devtools/python/python3-smbus/0001-Use-setuptools-as-distutils-is-deprecated.patch
new file mode 100644
index 0000000000..6aafd6a952
--- /dev/null
+++ b/meta-python/recipes-devtools/python/python3-smbus/0001-Use-setuptools-as-distutils-is-deprecated.patch
@@ -0,0 +1,25 @@
+Upstream-Status: Submitted [https://lore.kernel.org/linux-i2c/20220114134910.3994688-1-ross.burton@arm.com/T/#u]
+Signed-off-by: Ross Burton <ross.burton@arm.com>
+
+From fa522a9a390b1857a58ec1f55da1465c542fd106 Mon Sep 17 00:00:00 2001
+From: Ross Burton <ross.burton@arm.com>
+Date: Fri, 14 Jan 2022 13:38:34 +0000
+Subject: [PATCH] Use setuptools as distutils is deprecated
+
+Signed-off-by: Ross Burton <ross.burton@arm.com>
+---
+ py-smbus/setup.py | 2 +-
+ 1 file changed, 1 insertion(+), 1 deletion(-)
+
+diff --git a/py-smbus/setup.py b/py-smbus/setup.py
+index 28a4500..26db33a 100644
+--- a/py-smbus/setup.py
++++ b/py-smbus/setup.py
+@@ -1,6 +1,6 @@
+ #!/usr/bin/env python
+ 
+-from distutils.core import setup, Extension
++from setuptools import setup, Extension
+ 
+ setup(	name="smbus",
+ 	version="1.1",
diff --git a/meta-python/recipes-devtools/python/python3-smbus_4.3.bb b/meta-python/recipes-devtools/python/python3-smbus_4.3.bb
index a09a108b36..ecdff3adad 100644
--- a/meta-python/recipes-devtools/python/python3-smbus_4.3.bb
+++ b/meta-python/recipes-devtools/python/python3-smbus_4.3.bb
@@ -2,13 +2,15 @@ SUMMARY = "Set of i2c tools for linux - Python module"
 LICENSE = "GPLv2"
 LIC_FILES_CHKSUM = "file://py-smbus/smbusmodule.c;beginline=1;endline=18;md5=46e424fb045901ab25e0f92c28c80055"
 
-SRC_URI = "${KERNELORG_MIRROR}/software/utils/i2c-tools/i2c-tools-${PV}.tar.gz "
+SRC_URI = "${KERNELORG_MIRROR}/software/utils/i2c-tools/i2c-tools-${PV}.tar.gz \
+           file://0001-Use-setuptools-as-distutils-is-deprecated.patch \
+           "
 SRC_URI[sha256sum] = "eec464e42301d93586cbeca3845ed61bff40f560670e5b35baec57301d438148"
 
 DEPENDS += "i2c-tools"
 
 S = "${WORKDIR}/i2c-tools-${PV}"
 
-inherit distutils3
+inherit setuptools3
 
-DISTUTILS_SETUP_PATH = "${S}/py-smbus"
+SETUPTOOLS_SETUP_PATH = "${S}/py-smbus"